BDBM552096 (18*R)-12-hydroxy-18-phenyl-5,6,7,8,9,18-hexahydro-10,17-methanodipyrido[1,2-b:2′,3′-k][1,2,5]triazacyclotridecine-11,13-dione (Compound 23A) and (18*S)-12-hydroxy-18-phenyl-5,6,7,8,9,18-hexahydro-10,17-methanodipyrido[1,2-b:2′,3′-k][1,2,5]triazacyclotridecine-11,13-dione ::US11312727, Compound 23B

SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4cccnc4CCCCC3)n2ccc1=O

InChI Key InChIKey=UBSYUBUPGDYZAX-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552096   

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552096((18*R)-12-hydroxy-18-phenyl-5,6,7,8,9,18-hexahydro...)
Affinity DataEC50:  1.22E+4nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552096((18*R)-12-hydroxy-18-phenyl-5,6,7,8,9,18-hexahydro...)
Affinity DataIC50: 240nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent