BDBM552092 (17*R,*Z)-4-hydroxy-16-phenyl-7,10,11,16-tetrahydro-6,17-methanobenzo[k]pyrido[1,2-b][1,2,5]triazacyclotridecine-3,5-dione (Compound 21A) and (17*S,*Z)-4-hydroxy-16-phenyl-7,10,11,16-tetrahydro-6,17-methanobenzo[k]pyrido[1,2-b][1,2,5]triazacyclotridecine-3,5-dione ::US11312727, Compound 21B::US11312727, Compound 52B

SMILES Oc1c2C(=O)N3CN([C@@H](c4ccccc4)c4ccccc4CC\C=C/C3)n2ccc1=O

InChI Key InChIKey=CLGZFVMPGIPDKB-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 552092   

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552092(US11312727, Compound 52B | (17*R,*Z)-4-hydroxy-16-...)
Affinity DataEC50:  815nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552092(US11312727, Compound 52B | (17*R,*Z)-4-hydroxy-16-...)
Affinity DataIC50: 128nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552092(US11312727, Compound 52B | (17*R,*Z)-4-hydroxy-16-...)
Affinity DataEC50:  84nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552092(US11312727, Compound 52B | (17*R,*Z)-4-hydroxy-16-...)
Affinity DataIC50: 40nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent