BDBM552083 (*E)-15-hydroxy-2-phenyl-12,13,14,16-tetrahydro-11H-1(1,3)-pyrido[2,1-f][1,2,4]triazina-3(1,2)-benzenacyclononaphan-6-ene-14,16-dione ::US11312727, Compound 14

SMILES Oc1c2C(=O)N3CN(C(c4ccccc4)c4ccccc4CC\C=C\CC3)n2ccc1=O

InChI Key InChIKey=UKDQTMWIDAACQP-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552083   

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552083((*E)-15-hydroxy-2-phenyl-12,13,14,16-tetrahydro-11...)
Affinity DataEC50:  48nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552083((*E)-15-hydroxy-2-phenyl-12,13,14,16-tetrahydro-11...)
Affinity DataIC50: 67nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent