BDBM551398 US11312713, Example 95::[5-({8-chloro-1-[(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-1H-imidazo[4,5-c]quinolin-2-yl}methyl)pyrazin-2-yl]methanol

SMILES C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(CO)cn2)nc2cnc3ccc(F)cc3c12

InChI Key InChIKey=HSTKJGNVNYHXRI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 551398   

LigandPNGBDBM551398([5-({8-chloro-1-[(2R,4R)-2-methyltetrahydro-2H-pyr...)
Affinity DataIC50: 3.5nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551398([5-({8-chloro-1-[(2R,4R)-2-methyltetrahydro-2H-pyr...)
Affinity DataIC50: 4.60nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent