BDBM551386 8-chloro-1-(4,4-difluoro-1-methylpyrrolidin-3-yl)- 2-(1H-tetrazol-1-ylmethyl)-1H-imidazo[4,5- c]quinoline, trifluoroacetate salt::US11312713, Example 83::US11312713, Example 86

SMILES CN1CC(n2c(Cn3cnnn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

InChI Key InChIKey=PZOOYRZEJBBJQG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 551386   

LigandPNGBDBM551386(US11312713, Example 86 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 4.40nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551386(US11312713, Example 86 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 6.66nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551386(US11312713, Example 86 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 7.91nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551386(US11312713, Example 86 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 11.6nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent