BDBM551354 8-chloro-1-(4,4-difluoro-1-methylpyrrolidin-3-yl)- 2-[(5-methyl-1,2-oxazol-3-yl)methyl]-1H-imidazo [4,5-c]quinoline, ENT 1::US11312713, Example 51::US11312713, Example 52

SMILES CN1CC(n2c(Cc3cc(C)on3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

InChI Key InChIKey=UDXAXCRORVOLCH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 551354   

LigandPNGBDBM551354(US11312713, Example 52 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 3.49nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551354(US11312713, Example 52 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 5.78nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551354(US11312713, Example 52 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 12.9nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551354(US11312713, Example 52 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 15.1nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent