BDBM551353 8-chloro-1-(4,4-difluoro-1-methylpyrrolidin-3-yl)- 2-[(5-methylpyrazin-2-yl)methyl]-1H-imidazo[4,5- c]quinoline, ENT 1::US11312713, Example 50

SMILES CN1CC(n2c(Cc3cnc(C)cn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

InChI Key InChIKey=KHSSKAIROFJTQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 551353   

LigandPNGBDBM551353(8-chloro-1-(4,4-difluoro-1-methylpyrrolidin-3-yl)-...)
Affinity DataIC50: 1.11nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551353(8-chloro-1-(4,4-difluoro-1-methylpyrrolidin-3-yl)-...)
Affinity DataIC50: 5.06nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent