BDBM551348 8-chloro-1-(4,4-difluoro-1-methylpyrrolidin-3-yl)- 2-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1H- imidazo[4,5-c]quinoline, trifluoroacetate salt::US11312713, Example 45::US11312713, Example 88

SMILES CN1CC(n2c(Cc3noc(C)n3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

InChI Key InChIKey=YVFMOFCDPODUPW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 551348   

LigandPNGBDBM551348(US11312713, Example 88 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 5.82nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551348(US11312713, Example 88 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 8.13nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551348(US11312713, Example 88 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 8.16nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551348(US11312713, Example 88 | 8-chloro-1-(4,4-difluoro-...)
Affinity DataIC50: 9.25nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent