BDBM551344 2-[(4-methoxy-1H-pyrazol-1-yl)methyl]-1- [(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-8- (trifluoromethyl)-1H-imidazo[4,5-c]quinoline::US11312713, Example 41

SMILES COc1cnn(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CCO[C@H](C)C2)C(F)(F)F)c1

InChI Key InChIKey=RRPCZAZAUKRYQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 551344   

LigandPNGBDBM551344(2-[(4-methoxy-1H-pyrazol-1-yl)methyl]-1- [(2R,4R)-...)
Affinity DataIC50: 3.87nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551344(2-[(4-methoxy-1H-pyrazol-1-yl)methyl]-1- [(2R,4R)-...)
Affinity DataIC50: 11.1nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent