BDBM551323 1-(4,4-Difluoro-1-methylpyrrolidin-3-yl)-8-fluoro-2-[(5-methylpyrazin-2-yl)methyl]-1H-imidazo[4,5-c]quinoline, ENT 1 (20) and 1-(4,4-Difluoro-1-methylpyrrolidin-3-yl)-8-fluoro-2-[(5-methylpyrazin-2-yl)methyl]-1H-imidazo[4,5-c]quinoline, ENT 2 (21)::US11312713, Example 20

SMILES CN1C[C@H](n2c(Cc3cnc(C)cn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1

InChI Key InChIKey=JWHNZKQHRKBAGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 551323   

LigandPNGBDBM551323(1-(4,4-Difluoro-1-methylpyrrolidin-3-yl)-8-fluoro-...)
Affinity DataIC50: 3.31nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM551323(1-(4,4-Difluoro-1-methylpyrrolidin-3-yl)-8-fluoro-...)
Affinity DataIC50: 4.12nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent