BDBM550493 US11306105, Compound 109

SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCC(F)F)c1nnc(C)n-21)c1ccc(cc1)C#N

InChI Key InChIKey=PKFVMDLBSYTDCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 550493   

TargetBromodomain testis-specific protein [22-138](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM550493(US11306105, Compound 109)
Affinity DataIC50: 142nMAssay Description:Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM550493(US11306105, Compound 109)
Affinity DataIC50: 37nMAssay Description:Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
Go to US Patent