BDBM549561 US11306075, Ex. 5::US20240158379, Example 5

SMILES COc1cccc(c1)-c1ccc2oc(CCC(C)=O)c(-c3ccc(C)o3)c2c1

InChI Key InChIKey=MVDXGIGDGSTUKG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 549561   

TargetMicrotubule-associated protein tau(Human)
Oligomerix

US Patent
LigandPNGBDBM549561(US11306075, Ex. 5 | US20240158379, Example 5)
Affinity DataIC50: 3.03E+3nMAssay Description:Tau target (equal mixture of each construct at 300 nM) was prepared in buffer (Tris-HCl pH 7.4) and was incubated in 96-well plates at room temperatu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
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TargetMicrotubule-associated protein tau(Human)
Oligomerix

US Patent
LigandPNGBDBM549561(US11306075, Ex. 5 | US20240158379, Example 5)
Affinity DataIC50: 3.03E+3nMAssay Description:AlphaLisa Assay (ALA) was used as a primary screen for identifying compounds that inhibit tau oligomer formation. It is a bead based assay that only ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetMicrotubule-associated protein tau(Human)
Oligomerix

US Patent
LigandPNGBDBM549561(US11306075, Ex. 5 | US20240158379, Example 5)
Affinity DataIC50: 364nMAssay Description:Confirmatory Assay (CONFA) used as a secondary screen for confirming the mechanism of action of compounds identified as hits using the ALA assay. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent