BDBM549532 N-(4-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazolin-8-yl)pyridin-::US11304957, Compound C057

SMILES FC(F)CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)cc1

InChI Key InChIKey=AHSWNWCHSHAILG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549532   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Neupharma

US Patent
LigandPNGBDBM549532(N-(4-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)q...)
Affinity DataIC50: 100nMAssay Description:EGFR (T790M)(L858R):The 2×EGFR (ErbB1) T790M L858R/Tyr 04 mixture is prepared in 50 mM HEPES pH 6.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, 0.02% NaN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
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