BDBM549179 (5R)-N2-ethyl-5-oxido-N4-tetrahydropyran-4-yl-N2-(2-tetrahydropyran-4-ylethyl)-6,7-dihydrothieno[3,2-d]pyrimidin-5-ium-2,4-diamine::US11299497, Example 2

SMILES CCN(CCC1CCOCC1)c1nc2CC[S@@+]([O-])c2c(NC2CCOCC2)n1

InChI Key InChIKey=UXCHMVPQIGTLTL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549179   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D [380-741](Human)
Union Therapeutics

US Patent
LigandPNGBDBM549179((5R)-N2-ethyl-5-oxido-N4-tetrahydropyran-4-yl-N2-(...)
Affinity DataIC50: 10nMAssay Description:The human PDE41 Dcatalytic domain (UniProt no. Q08499 [S380-L740]) was incubated with a mixture of non-labelled cAMP (cyclic adenosine monophosphate)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
Go to US Patent