BDBM549132 BDBM50556940::US11299480, Example 138

SMILES Fc1c(F)c(F)c(c(F)c1F)S(=O)(=O)N1CC[C@@H]1C(=O)N(Cc1ccc(cn1)C1CCCCC1)c1ccc2C(=O)NC(=O)c2c1

InChI Key InChIKey=DFAZGBBGEGHQMP-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 549132   

TargetSignal transducer and activator of transcription 3(Human)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549132(BDBM50556940 | US11299480, Example 138)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain (unknown origin) preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549132(BDBM50556940 | US11299480, Example 138)
Affinity DataKd:  960nMAssay Description:Binding affinity to STAT3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 1/3(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549132(BDBM50556940 | US11299480, Example 138)
Affinity DataIC50: 4.71E+3nMAssay Description:Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT1/STAT3 heterodimer in mouse NIH3T3 nuclear extract pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 1(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549132(BDBM50556940 | US11299480, Example 138)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT1 homodimer in mouse NIH3T3 nuclear extract preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549132(BDBM50556940 | US11299480, Example 138)
Affinity DataIC50: 4.00E+3nMAssay Description:Nuclear extract preparations and DNA-binding activity/electrophoretic mobility shift assay (EMSA) were carried out as previously described (Zhang X, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2022
Entry Details
Go to US Patent