BDBM548467 WO2022093881, Ex-7.4

SMILES C[C@]1(COC[C@@H]1O)N2CCN(CC2)c3cc4cc(ncc4cc3Cl)NC(=O)[C@H]5CC56CCOCC6

InChI Key InChIKey=ISEBFQYGEPKLRU-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 548467   

LigandPNGBDBM548467(WO2022093881, Ex-7.4)
Affinity DataIC50: 0.780nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022093881

LigandPNGBDBM548467(WO2022093881, Ex-7.4)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) using LRRKtide peptide as substrate assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed