BDBM547914 WO2022090481, Example I-135

SMILES COc1ccncc1-c1cc2n(ncc2c(C)n1)-c1cc2n(C)nc(C)c2c(n1)N1CCOCC1

InChI Key InChIKey=WGJHQRPJYBPHOA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 547914   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547914(WO2022090481, Example I-135)
Affinity DataIC50: 1.5nMAssay Description: Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481