BDBM5470 6-methoxy-9H-purin-2-amine::CHEMBL226395::O6-Substituted Guanine Deriv. 1

SMILES COc1nc(N)nc2nc[nH]c12

InChI Key InChIKey=BXJHWYVXLGLDMZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 5470   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
University of Newcastle

LigandPNGBDBM5470(CHEMBL226395 | 6-methoxy-9H-purin-2-amine | O6-Sub...)
Affinity DataAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2005
Entry Details Article
PubMed
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Human)
University of Newcastle

LigandPNGBDBM5470(CHEMBL226395 | 6-methoxy-9H-purin-2-amine | O6-Sub...)
Affinity DataAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2005
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5470(CHEMBL226395 | 6-methoxy-9H-purin-2-amine | O6-Sub...)
Affinity DataIC50: 2.48E+5nMAssay Description:concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5470(CHEMBL226395 | 6-methoxy-9H-purin-2-amine | O6-Sub...)
Affinity DataIC50: 4.28E+5nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Institute of Biological Chemistry and The Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM5470(CHEMBL226395 | 6-methoxy-9H-purin-2-amine | O6-Sub...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5470(CHEMBL226395 | 6-methoxy-9H-purin-2-amine | O6-Sub...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2019
Entry Details Article
PubMed