BDBM546731 (3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-dimethylpiperazine- 1-yl)methyl)phenyl)amino)pyrimidine- 4-yl)-1H-indole-6-yl)methanol::US11292786, Example 16

SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3cn(c4cc(CO)ccc34)S(=O)(=O)c3ccc(C)cc3)cc(c2)C2CC2)C[C@@H](C)N1

InChI Key InChIKey=IUFSHQSJWMOYMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 546731   

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM546731((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM546731((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent