BDBM546710 US11292782, Compound 39

SMILES Cc1ncsc1C(=O)NCc1ccc(cc1)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=XOZCUECTGOQYMO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 546710   

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM546710(US11292782, Compound 39)
Affinity DataIC50: 200nMAssay Description:Human AR cDNA cloned into pCMV vector, GRE-LUC, and CMV-renilla-LUC were used to transfect cells. HEK-293 cells (ATCC) were plated at 120,000 cells p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
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TargetGlucocorticoid receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM546710(US11292782, Compound 39)
Affinity DataIC50: 1.00E+4nMAssay Description:COS-7 cells (ATCC, Manassas, Va.) were plated in 24 well plates in DME+5% csFBS without phenol red at 70,000 cells/well. Once the cells attached to t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent