BDBM54640 4-[3-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-4,5-dihydropyrazol-1-yl]-benzene-sulfonamide (10f)::4-[3-(4-chlorophenyl)-5-(4-methoxyphenyl)-2-pyrazolin-1-yl]benzenesulfonamide::4-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzenesulfonamide::KUC103415N::UNM-0000306132::cid_42628051

SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(Cl)cc1

InChI Key InChIKey=QRIHFWVYVVPTKX-UHFFFAOYSA-N

Data  2 KI  2 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 54640   

TargetRas-related protein Rab-2A(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetGTPase KRas [1-37](Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetGTPase KRas [1-37](Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  2.30E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  4.06E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetRas-related protein Rab-7a(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetProstaglandin G/H synthase 2(Sheep)
Beni-Suef University

LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataIC50: 740nMAssay Description:The in vitro inhibition of ovine COX-1 and COX-2 was measured using an enzyme immuno assay (EIA) kit (Cayman Chemical, Ann Arbor, MI, USA) according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Beni-Suef University

LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataIC50: 6.52E+3nMAssay Description:The in vitro inhibition of ovine COX-1 and COX-2 was measured using an enzyme immuno assay (EIA) kit (Cayman Chemical, Ann Arbor, MI, USA) according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataKi:  490nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54640(cid_42628051 | KUC103415N | 4-[5-(4-chlorophenyl)-...)
Affinity DataKi:  630nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay