BDBM54586 4-[3-(3,4-dimethoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide::4-[5-(3,4-dimethoxyphenyl)-3-phenyl-2-pyrazolin-1-yl]benzenesulfonamide::UNM-0000305823::cid_2971684

SMILES COc1ccc(cc1OC)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccccc1

InChI Key InChIKey=YEWYWWRBZDDFMO-UHFFFAOYSA-N

Data  8 KI  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 54586   

TargetRas-related protein Rab-2A(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetGTPase KRas [1-37](Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetGTPase KRas [1-37](Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  1.32E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  5.70E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  6.05E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetRas-related protein Rab-7a(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetCarbonic anhydrase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  27nMAssay Description:Binding affinity to human CA2 assessed as inhibition constant by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  27nMAssay Description:Inhibition of human CA2 by UV spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  28nMAssay Description:Binding affinity to human CA1 assessed as inhibition constant by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  28nMAssay Description:Inhibition of human CA1 by UV spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  38nMAssay Description:Inhibition of AChE (unknown origin) by UV spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  940nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  1.21E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM54586(UNM-0000305823 | cid_2971684 | 4-[3-(3,4-dimethoxy...)
Affinity DataKi:  1.24E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay