BDBM5456 6-alkoxy-4-anilinoquinazoline 8b::N-(3-ethynylphenyl)-6-{4-[(2-methanesulfonylethyl)amino]butoxy}quinazolin-4-amine

SMILES CS(=O)(=O)CCNCCCCOc1ccc2ncnc(Nc3cccc(c3)C#C)c2c1

InChI Key InChIKey=WLLKPDBSPXZCTG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5456   

TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5456(N-(3-ethynylphenyl)-6-{4-[(2-methanesulfonylethyl)...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5456(N-(3-ethynylphenyl)-6-{4-[(2-methanesulfonylethyl)...)
Affinity DataIC50: 234nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed