BDBM544012 US11279719, Example I-44

SMILES COc1ccc(NC(=O)c2cccc(c2)-c2nc(NC(P(O)(O)=O)P(O)(O)=O)c3ncn(C)c3n2)cc1F

InChI Key InChIKey=FUWHZYQQGUBKPH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 544012   

TargetGeranylgeranyl pyrophosphate synthase(Human)
Royal Institution For The Advancement of Learning

US Patent
LigandPNGBDBM544012(US11279719, Example I-44)
Affinity DataIC50: 2.55E+3nMAssay Description:The assay was based on a literature procedure (Kavanagh, et al. J. Biol. Chem., 2006, 281, 22004-22012) with minor modifications. All assays were run...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetGeranylgeranyl pyrophosphate synthase(Human)
Royal Institution For The Advancement of Learning

US Patent
LigandPNGBDBM544012(US11279719, Example I-44)
Affinity DataIC50: 58nMAssay Description:Inhibition of N-terminal His6 tagged human GGPPS expressed in Escherichia coli BL21(DE3) cells in presence of FPP and [14C]IPP by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed