BDBM544004 US11279719, Example I-36

SMILES OP(O)(=O)C(Nc1nc(nc2sccc12)-c1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)P(O)(O)=O

InChI Key InChIKey=FBYAUALUCDPPBY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 544004   

TargetGeranylgeranyl pyrophosphate synthase(Human)
Royal Institution For The Advancement of Learning

US Patent
LigandPNGBDBM544004(US11279719, Example I-36)
Affinity DataIC50: 100nMAssay Description:The assay was based on a literature procedure (Kavanagh, et al. J. Biol. Chem., 2006, 281, 22004-22012) with minor modifications. All assays were run...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetGeranylgeranyl pyrophosphate synthase(Human)
Royal Institution For The Advancement of Learning

US Patent
LigandPNGBDBM544004(US11279719, Example I-36)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
Royal Institution For The Advancement of Learning

US Patent
LigandPNGBDBM544004(US11279719, Example I-36)
Affinity DataIC50: 18nMAssay Description:Inhibition of N-terminal His6 tagged human GGPPS expressed in Escherichia coli BL21(DE3) cells in presence of FPP and [14C]IPP by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed