BDBM543896 (1S,3'R,6'R,7'S,11'S,12'R)- 6-chloro-7'- (hydroxymethyl)-12'-(2- methoxyethyl)-11'- methyl-3,4-dihydro- 2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-15'-one 13',13'-dioxide OR::US11279712, Example 29::US11279712, Example 59

SMILES COCC[C@@H]1[C@@H](C)CCC[C@H](CO)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS1(=O)=O

InChI Key InChIKey=HSTIHLWMVBCNMR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 543896   

LigandPNGBDBM543896(US11279712, Example 59 | (1S,3'R,6'R,7'S,11'S,12'R...)
Affinity DataIC50: 0.226nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

LigandPNGBDBM543896(US11279712, Example 59 | (1S,3'R,6'R,7'S,11'S,12'R...)
Affinity DataIC50: 0.921nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent