BDBM543745 US11279703, TABLE 6.335

SMILES CCC1(CC1)S(=O)(=O)Nc1cccc(c1)-n1ccc2cnc(Nc3ccc(cc3)N3CCC(CC3)N(C)C)nc12

InChI Key InChIKey=XMAQKLWTIVZGRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 543745   

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543745(US11279703, TABLE 6.335)
Affinity DataIC50: 1.40E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543745(US11279703, TABLE 6.335)
Affinity DataIC50: 4.70nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent