BDBM543570 US11279703, TABLE 6.159::US11643396, Example SG4-033

SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(C)c(Nc3ccc4CCN(c4c3)S(=O)(=O)C(C)(C)C)n2)cc1F

InChI Key InChIKey=IKKUVCXGUJTONF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 543570   

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 87nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 24nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 30nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 157nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 92nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [22-138](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 131nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 1.01E+3nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM543570(US11279703, TABLE 6.159 | US11643396, Example SG4-...)
Affinity DataIC50: 8.60nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent