BDBM543486 US11279703, TABLE 6.108::US11279703, TABLE 6.127::US11279703, TABLE 6.330::US11279703, Table 2.5

SMILES CN1CCC(CC1)Nc1nc(Nc2ccc3CCN(c3c2)S(=O)(=O)C(C)(C)C)c2ccsc2n1

InChI Key InChIKey=GFVREQSKPNZXLD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 543486   

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 160nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 160nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 220nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 293nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 315nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 331nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 776nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 543486BDBM543486(US11279703, Table 2.5 | US11279703, TABLE 6.330 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent