BDBM5432 6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL92461::pyrazolo[1,5-a]pyrimidine 3g

SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1

InChI Key InChIKey=HBWLNACPIFKNIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5432   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5432(6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...)
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5432(6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...)
Affinity DataIC50: 185nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5432(6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorption by ELISA assay in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed