BDBM5416 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy}ethyl)morpholine::CHEMBL324153::dorsomorphin (6K1)::pyrazolo[1,5-a]pyrimidine 4h

SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1

InChI Key InChIKey=OOQJIJYKWXLQNC-UHFFFAOYSA-N

Data  10 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 5416   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataEC50:  1.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataEC50:  5.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetBone morphogenetic protein 4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BMP4-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 50nMAssay Description:Inhibition of c-SRC by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 250nMAssay Description:Inhibition of EphA2 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 210nMAssay Description:Inhibition of FLT1 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FLT3 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 56nMAssay Description:Inhibition of KDR by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 300nMAssay Description:Inhibition of LCK by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of RSK1 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed