BDBM538100 US11253516, Example 2

SMILES COc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1

InChI Key InChIKey=QLOZCEXTSVOFQC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 538100   

TargetEpidermal growth factor receptor(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538100(US11253516, Example 2)
Affinity DataIC50: 730nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538100(US11253516, Example 2)
Affinity DataIC50: 12nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538100(US11253516, Example 2)
Affinity DataIC50: 12nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538100(US11253516, Example 2)
Affinity DataIC50: 3nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
Go to US Patent