BDBM5380 2,4-Disubstituted Pyrimidine 2d::N-(3,5-dimethylphenyl)-4-(2-phenyl-1H-imidazol-1-yl)pyrimidin-2-amine

SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1

InChI Key InChIKey=AAVVJYRIFZWOQJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5380   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5380(N-(3,5-dimethylphenyl)-4-(2-phenyl-1H-imidazol-1-y...)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5380(N-(3,5-dimethylphenyl)-4-(2-phenyl-1H-imidazol-1-y...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed