BDBM537926 US11248003, Example 1

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2N(C)S(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=OZRNZXPMNJNRPE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 537926   

LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 0.0800nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Oncobix

US Patent
LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 1nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed