BDBM536918 US11896597, Compound 43

SMILES COc1cc(N2CCC[C@@H]2CN(C)C)c(NC(=O)C=C)cc1Nc1ncnc(Nc2cc(F)c(Cl)cc2C(C)(C)O)n1

InChI Key InChIKey=OFQRNJAHCAMAME-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 536918   

TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM536918(US11896597, Compound 43)
Affinity DataIC50: 3.90nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
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TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM536918(US11896597, Compound 43)
Affinity DataIC50: 5.90nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM536918(US11896597, Compound 43)
Affinity DataIC50: 0.300nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM536918(US11896597, Compound 43)
Affinity DataIC50: 2.90nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM536918(US11896597, Compound 43)
Affinity DataIC50: 8.10nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
Go to US Patent