BDBM53662 2-Methanesulfonyl-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-ylamine::2-methylsulfonyl-4-phenyl-6-thiophen-2-yl-3-thieno[2,3-b]pyridinamine::2-methylsulfonyl-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-amine::2-methylsulfonyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine::MLS000031458::SMR000012299::US10301320, ID SW033290::US10869871, ID # SW033290::US20230285402, ID # SW033290::US9789116, SW033290::[2-mesyl-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridin-3-yl]amine::cid_654955

SMILES CS(=O)(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1

InChI Key InChIKey=VJLXCXYDRATFPQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 53662   

TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM53662(2-methylsulfonyl-4-phenyl-6-thiophen-2-yl-3-thieno...)
Affinity DataIC50: 8.11E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Case Western Reserve University

US Patent
LigandPNGBDBM53662(2-methylsulfonyl-4-phenyl-6-thiophen-2-yl-3-thieno...)
Affinity DataIC50: 525nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH in an in vitro assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Case Western Reserve University

US Patent
LigandPNGBDBM53662(2-methylsulfonyl-4-phenyl-6-thiophen-2-yl-3-thieno...)
Affinity DataIC50: 525nMAssay Description:In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Case Western Reserve University

US Patent
LigandPNGBDBM53662(2-methylsulfonyl-4-phenyl-6-thiophen-2-yl-3-thieno...)
Affinity DataIC50: 525nMAssay Description:This Example provides data on a group of structural analogues of SW033291. Data provided includes level of induction of a 15-PGDH-luciferase fusion g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent