BDBM536505 (S)-7-(1-(2-((3-chloro- 6-(2,4-dimethylpipera- zin-1-yl)-2-fluoro- pyridin-4-yl)amino)-2- oxoethyl)-4-oxo- 4,6,7,8-tetrahydro-1H- dipyrrolo[1,2-a:2',3'-d] pyrimidin-3-yl)-4- hydroxybenzo[d][1,3] dioxole-5-carboxamide::US11242351, Compound I-84::acsmedchemlett.2c00502 OICR 13911D, 57

SMILES C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c4OCOc34)c3c2nc2CCCn2c3=O)c(Cl)c(F)n1

InChI Key InChIKey=WXJSHBZZQMZOFB-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536505   

TargetB-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429](Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM536505((S)-7-(1-(2-((3-chloro- 6-(2,4-dimethylpipera- zin...)
Affinity DataKd:  0.530nMAssay Description:This assay was used to determine whether compounds inhibit the interaction between the BTB domain of BCL6 and a peptide derived from the BCL6 binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM536505((S)-7-(1-(2-((3-chloro- 6-(2,4-dimethylpipera- zin...)
Affinity DataKd:  0.5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM536505((S)-7-(1-(2-((3-chloro- 6-(2,4-dimethylpipera- zin...)
Affinity DataKd:  0.5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed