BDBM536470 (S)-5-(1-(2-((3-chloro- 6-(2,4-dimethyl- piperazin-1-yl)-2- fluoropyridin-4-yl) amino)-2-oxoethyl)-4- oxo-4,6,7,8,9,10- hexahydro-1H-pyrrolo [2',3':4,5]pyrimido [1,2-a]azepin-3-yl)- 3,4-difluoro-2-hydroxy- benzamide::US11242351, Compound I-49::acsmedchemlett.2c00502 OICR 13231D, 60

SMILES C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c2nc2CCCCCn2c3=O)c(Cl)c(F)n1

InChI Key InChIKey=WVAPBIZHYDNDKJ-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536470   

TargetB-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429](Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM536470((S)-5-(1-(2-((3-chloro- 6-(2,4-dimethyl- piperazin...)
Affinity DataKd:  46.6nMAssay Description:This assay was used to determine whether compounds inhibit the interaction between the BTB domain of BCL6 and a peptide derived from the BCL6 binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM536470((S)-5-(1-(2-((3-chloro- 6-(2,4-dimethyl- piperazin...)
Affinity DataKd:  47nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM536470((S)-5-(1-(2-((3-chloro- 6-(2,4-dimethyl- piperazin...)
Affinity DataKd:  47nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed