BDBM535978 N-{[4-(Aminomethyl)-2-methylphenyl]methyl}-5-({4-[(4-methylpyrazol-::US11242333, Example 93

SMILES Cc1cnn(Cc2ccc(Cc3cccc(c3)C(=O)NCc3ccc(CN)cc3C)cc2)c1

InChI Key InChIKey=GISQVARMDIQSOG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535978   

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM535978(N-{[4-(Aminomethyl)-2-methylphenyl]methyl}-5-({4-[...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
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TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM535978(N-{[4-(Aminomethyl)-2-methylphenyl]methyl}-5-({4-[...)
Affinity DataIC50: 14.4nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent