BDBM535951 N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(diethylamino)pyridin-3-::US11242333, Example 66

SMILES CN(C)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1

InChI Key InChIKey=OOGPOIMLTCOJDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535951   

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM535951(N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(diethyl...)
Affinity DataIC50: 5.85E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
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TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM535951(N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(diethyl...)
Affinity DataIC50: 52.7nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent