BDBM535861 N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-methylpiperazin-1-yl)nicotinamide::US11241428, Example 13::US11241428, Example 6

SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1nc(ccc1N)-c1ccc(F)cc1

InChI Key InChIKey=TUVFSLMAKAPSFZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 535861   

TargetHistone deacetylase 1(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 200nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 200nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 5.00E+4nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 5.00E+4nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 5.00E+4nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 2.55E+4nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Medibiofarma

US Patent
LigandPNGBDBM535861(N-(3-amino-6-(4-fluorophenyl)pyridin-2-yl)-6-(4-me...)
Affinity DataIC50: 200nMAssay Description:The inhibitory activities of compounds of present invention were determined using biochemical HDAC assays (Reaction Biology Corp. biochemical assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2022
Entry Details
Go to US Patent