BDBM535796 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-yl)methyl]-4-fluoro- 6-[(1S)-1-hydroxy-1-[1-(2- hydroxyethyl)piperidin-4-yl]propyl]-3- methoxy-2,3-dihydro-1H-isoindol-1- one Ex. 550 is the faster eluting isomer::US11236047, Example 550

SMILES CC[C@](O)(C1CCN(CCO)CC1)c1cc2C(=O)N(Cc3ncc(Cl)cn3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=JRFKQIQQIAJEPR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535796   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535796((3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-y...)
Affinity DataIC50: 0.980nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
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