BDBM535783 2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-{1-hydroxy-1-[trans-4- hydroxycyclohexyl]propyl}-1-[(2R)-2- hydroxypropoxy]-3-oxo-2,3-dihydro- 1H-isoindol-2-yl]methyl}pyrimidine-5- carbonitrile::US11236047, Example 512

SMILES CCC(O)([C@H]1CC[C@H](O)CC1)c1cc2C(=O)N(Cc3ncc(cn3)C#N)[C@](OC[C@@H](C)O)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=MFJXVQCJOJBJSN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535783   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535783(2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-{1-hydroxy...)
Affinity DataIC50: 0.480nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
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