BDBM535703 2-(6-Azaspiro[2.5]octan-6- yl)-N-(2-(4,4-difluoro-1- pieridinyl)-6-methyl-4- pyrimidinyl)-4-(R- ethylsulfonimidoyl)benzamide::US11236069, Example 19-4

SMILES CC[S@](=N)(=O)c1ccc(C(=O)Nc2cc(C)nc(n2)N2CCC(F)(F)CC2)c(c1)N1CCC2(CC2)CC1

InChI Key InChIKey=GWXXNOCVCAJYOK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535703   

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandPNGBDBM535703(2-(6-Azaspiro[2.5]octan-6- yl)-N-(2-(4,4-difluoro-...)
Affinity DataIC50: 35nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
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