BDBM535526 N-(2-(4,4-Difluoropiperidin-1- yl)pyridin-4-yl)-4-(N-(3-methyloxetan- 3-yl)sulfamoyl)-2-(6- azaspiro[2.5]octan-6-yl)benzamide::US11236069, Example 2-4

SMILES CC1(COC1)NS(=O)(=O)c1ccc(C(=O)Nc2ccnc(c2)N2CCC(F)(F)CC2)c(c1)N1CCC2(CC2)CC1

InChI Key InChIKey=XIRIHHJZSDATMZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535526   

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandPNGBDBM535526(N-(2-(4,4-Difluoropiperidin-1- yl)pyridin-4-yl)-4-...)
Affinity DataIC50: 29nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent