BDBM535446 6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[hydroxy(1-methyl-1H-pyrazol-4- yl)methyl]-3-oxo-1-[(3S)-oxolan-3- yloxy]-2,3-dihydro-1H-isoindol-2- yl]methyl}pyridine-3-carbonitrile Ex. 357 is the slower eluting isomer::US11236047, Example 357::US11236047, Example 360::US20230338337, Compound 360
SMILES Cn1cc(cn1)C(O)c1cc2C(=O)N(Cc3ccc(cn3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1
InChI Key InChIKey=RRUBGLIKOBFXDA-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 535446
Affinity DataIC50: 1.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair