BDBM535432 US11236047, Example 183::US11236047, Example 184

SMILES CCn1cc(cn1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cn3)[C@](OCC3(O)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=QYPLRLGVDBPTMJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535432   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535432(US11236047, Example 184 | US11236047, Example 183)
Affinity DataIC50: 4.20nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535432(US11236047, Example 184 | US11236047, Example 183)
Affinity DataIC50: 0.920nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent