BDBM535379 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-4-fluoro-6- [1-hydroxy-1-(1-methyl-1H-pyrazol-4- yl)ethyl]-3-[trans-3- hydroxycyclobutoxy]-2,3-dihydro-1H- isoindol-1-one::US11236047, Example 206::US20230338337, Compound 206

SMILES Cn1cc(cn1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cn3)[C@](O[C@H]3C[C@H](O)C3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=FGIFVIRKAVOOKP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535379   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535379((3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 1.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
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TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535379((3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 1.5nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
Go to US Patent