BDBM535251 (3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-6-[1- hydroxy-1-(1-oxo-1lambda5-pyridin-3- yl)ethyl]-3-methoxy-2,3-dihydro-1H- isoindol-1-one::US11236047, Example 88::US11236047, Example 89

SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)C(C)(O)C1CCOCC1)c1ccc(Cl)cc1

InChI Key InChIKey=AVDHVIXZENQIRS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 535251   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535251((3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 0.790nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535251((3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 12nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535251((3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 11nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535251((3R)-3-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 28nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent