BDBM534562 3-(2-amino-[1,2,4]triazolo[1,5-α]pyri din-7-yl)-6-chl oro-2 -fluoro-N-((2R,3S)-2-fluoro-3-(4-fluorophenyl)-3-hydroxypropyl)benzamide::WO2022086828, Example 298

SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NC[C@@H](F)[C@@H](O)c2ccc(F)cc2)c1F

InChI Key InChIKey=IUSXFQNTDSJZSX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 534562   

TargetMixed lineage kinase domain-like protein(Human)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534562(3-(2-amino-[1,2,4]triazolo[1,5-α]pyri din-7-y...)
Affinity DataIC50: 2.90nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

WIPO
LigandPNGBDBM534562(3-(2-amino-[1,2,4]triazolo[1,5-α]pyri din-7-y...)
Affinity DataIC50: 0.5nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

LigandPNGBDBM534562(3-(2-amino-[1,2,4]triazolo[1,5-α]pyri din-7-y...)
Affinity DataIC50: 8.00E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 40 nM probe and 1 nM GST-tagged PIK3C5 in complex with PIK3R1 (Invitrogen #...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828